Principales études 2011 - 2012 :
Etudes institutionnelles :
* Cohort Study of Volunteers That Have Participated to Preventive HIV-1 Vaccine Trials (COHVAC, NCT00789789) ANRS »
* Trial Comparing Three Strategies of Vaccination Against the Virus of Hepatitis B in HIV Infected Patients (VIHVAC-B) (HB03, NCT 00480792) ANRS »
* Trial Comparing Two Strategies of Vaccination Against Hepatitis B in HIV-infected Patients Non Responding to Primary Immunization (B-BOOST) (HB04, NCT 00670839) ANRS »
* Clinical Trial to Evaluate the Immunogenicity and Safety of an Adjuvanted A(H1N1)v Influenza Vaccine and a Non-adjuvanted A(H1N1)v Influenza Vaccine in HIV-infected Patients (ANRS 151 Hifluvac, NCT 01008813) »
* EP46 NOVAA The Yellow Fever Vaccine Immunity in HIV Infected Patients : Development of New Assays for Virological and Immunological Monitoring in HIV Infected Patient (NCT 01426243) ANRS »
* Safety Study of Two Vaccine Strategies in Patients With Systemic Lupus Erythematosus (VACCILUP, NCT 00611663) APHP »
* Efficacy Safety Study of Flu Vaccine in Immunodepression Patients (MICIVAX, NCT 01022749) APHP »
* "Prime Boost" Vaccination Strategy Combining Conjugated Anti- Pneumococcal Vaccine (s0) and Polysaccharide Anti- Pneumococcal Vaccine (s4) Compared to Polysaccharide Anti- Pneumococcal Vaccine Alone (s4) In Patients With Common Variable Immunodeficiency (EVAD) (RBM 04-34, NCT01489618) INSERM »
Essais industriels :
- A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Participants Undergoing Hematopoietic Cell Transplants (HCTs) (Study No. V212-001 AM3, NCT 01229267) Merk »
- A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Adult Participants With Solid Tumor or Hematologic Malignancy (V212-011, NCT 01254630) Merk »
- A Study to Evaluate the Safety and Immunogenicity of Inactivated Varicella-Zoster Virus (VZV) Vaccine in Adults With HM Receiving Treatment With Anti-CD20 Monoclonal Antibodies (V212-013, NCT 01460719) Merk »
- Safety and Immunogenicity Study of a Diphtheria, Tetanus, Acellular Pertussis and Poliomyelitis Vaccine (REPEVAX) Followed by 2 Doses of a Diphtheria, Tetanus and Poliomyelitis Vaccine (REVAXIS) in Subjects of 40 Years of Age or Older (NCT 01287949) Sanofi Pasteur MSD »
- A Study to Test the Benefit of a New Anti-cancer Treatment in Patients With Unresectable Advanced Melanoma (PREDICT, NCT 00942162) GSK »
- GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer (MAGRIT, NCT 00480025) GSK »
- GSK 2132231A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Resected Melanoma (NCT 00796445) GSK »
- RBM2008-022 "Etude comparative des réponses pro-et anti-inflammatoire obtenues à partir des cellules du sang de cordon" Coll. biol. en cours.Institut Pasteur.
Perspectives pour les 5 prochaines années :
Dans le cadre du partenariat avec l'Institut Pasteur, plusieurs essais vaccinaux sont prévus.
Le CIC est partenaire de 3 projets internationaux, financés par les Framework Programs de la Communauté Européenne.
Poursuite des recherches cliniques portant sur l'évaluation des vaccins, dans des populations fragiles.
Développement de projets de recherche translationelle avec des équipes de recherche de l'Inserm, de l'Institut Pasteur et de l'Université Paris Descartes.pour mieux caractériser les réponses vaccinales.
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