Activités de recherche

Principales études 2011 - 2012 :

Etudes institutionnelles :

* Cohort Study of Volunteers That Have Participated to Preventive HIV-1 Vaccine Trials (COHVAC, NCT00789789) ANRS »

* Trial Comparing Three Strategies of Vaccination Against the Virus of Hepatitis B in HIV Infected Patients (VIHVAC-B) (HB03, NCT 00480792) ANRS »

* Trial Comparing Two Strategies of Vaccination Against Hepatitis B in HIV-infected Patients Non Responding to Primary Immunization (B-BOOST) (HB04, NCT  00670839) ANRS »

* Clinical Trial to Evaluate the Immunogenicity and Safety of an Adjuvanted A(H1N1)v Influenza Vaccine and a Non-adjuvanted A(H1N1)v Influenza Vaccine in HIV-infected Patients (ANRS 151 Hifluvac, NCT 01008813) »

* EP46 NOVAA The Yellow Fever Vaccine Immunity in HIV Infected Patients : Development of New Assays for Virological and Immunological Monitoring in HIV Infected Patient (NCT 01426243) ANRS »

* Safety Study of Two Vaccine Strategies in Patients With Systemic Lupus Erythematosus (VACCILUP, NCT 00611663) APHP »

* Efficacy Safety Study of Flu Vaccine in Immunodepression Patients (MICIVAX, NCT 01022749) APHP »

* "Prime Boost" Vaccination Strategy Combining Conjugated Anti- Pneumococcal Vaccine (s0) and Polysaccharide Anti- Pneumococcal Vaccine (s4) Compared to Polysaccharide Anti- Pneumococcal Vaccine Alone (s4) In Patients With Common Variable Immunodeficiency (EVAD) (RBM 04-34, NCT01489618) INSERM »

Essais industriels :

- A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Participants Undergoing Hematopoietic Cell Transplants (HCTs) (Study No. V212-001 AM3, NCT 01229267) Merk  »

- A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Adult Participants With Solid Tumor or Hematologic Malignancy (V212-011, NCT 01254630) Merk »

- A Study to Evaluate the Safety and Immunogenicity of Inactivated Varicella-Zoster Virus (VZV) Vaccine in Adults With HM Receiving Treatment With Anti-CD20 Monoclonal Antibodies (V212-013, NCT 01460719) Merk »

- Safety and Immunogenicity Study of a Diphtheria, Tetanus, Acellular Pertussis and Poliomyelitis Vaccine (REPEVAX) Followed by 2 Doses of a Diphtheria, Tetanus and Poliomyelitis Vaccine (REVAXIS) in Subjects of 40 Years of Age or Older (NCT 01287949) Sanofi Pasteur MSD »

- A Study to Test the Benefit of a New Anti-cancer Treatment in Patients With Unresectable Advanced Melanoma (PREDICT, NCT 00942162) GSK »

- GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer (MAGRIT, NCT 00480025) GSK »

- GSK 2132231A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Resected Melanoma (NCT 00796445) GSK »

- RBM2008-022 "Etude comparative des réponses pro-et anti-inflammatoire obtenues à partir des cellules du sang de cordon" Coll. biol. en cours.Institut Pasteur.

Perspectives pour les 5 prochaines années :

• Dans le cadre du partenariat avec l'Institut Pasteur, plusieurs essais vaccinaux sont prévus.

• Le CIC est partenaire de 3 projets internationaux, financés par les Framework Programs de la Communauté Européenne.
  

• Poursuite des recherches cliniques portant sur l'évaluation des vaccins, dans des populations fragiles.
  

• Développement de projets de recherche translationelle avec des équipes de recherche de l'Inserm, de l'Institut Pasteur et de l'Université Paris Descartes.pour mieux caractériser les réponses vaccinales.